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In 1993, PERC was classified as a class A3 (animalcarcinogen), where it remains today. [ 121] studied the DNA methylation status of both P1and P2 promoters as a means of epigenetic transcriptional control of their corre-sponding isoforms in 102 primary NSCLCs and reported that the P2 hypomethylation-associated overexpression of ??p73 mRNA is a frequent event, particularly amongsquamous cell carcinomas

[ 121] studied the DNA methylation status of both P1and P2 promoters as a means of epigenetic transcriptional control of their corre-sponding isoforms in 102 primary NSCLCs and reported that the P2 hypomethylation-associated overexpression of ??p73 mRNA is a frequent event, particularly amongsquamous cell carcinomas.

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